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KMID : 1161420210240010050
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Journal of Medicinal Food
2021 Volume.24 No. 1 p.50 ~ p.58
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Antihypertensive Effects of Dehydroabietic and 4-Epi-Trans-Communic Acid Isolated from Pinus densiflora
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Park Jae-Young
Kim Won-Jin
Kim Woong
Park Cheol-Woo
Choi Chul-Yung
Cho Jang-Hee
Kim Seok-Jun
Cheong Hyeon-Sook
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Abstract
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Korean red pine needle (RPN) exhibits various biological and pharmacological activities. Among the various compounds of RPN, we isolated dehydroabietic and 4-epi-trans-communic acid. At first, we confirmed that two compounds inhibited angiotensin converting enzyme (ACE) and induced p-Akt in human umbilical vein endothelial cells (HUVEC). RPN extract powder significantly reduced systolic blood pressure in spontaneous hypertensive rats (SHRs) through the reduced expression of ACE and angiotensin type I receptors in the lungs of SHRs. The Lineweaver?Burk plots suggested that the two compounds were noncompetitive inhibitors of ACE. Using docking analysis, we found that two compounds showed the best returned pose at ACE active sites, and formed hydrogen and hydrophobic bonds with ACE residues. These results demonstrate that RPNs may be a source of compounds effective for preventing hypertension and may be useful in the development of antihypertensive drugs.
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KEYWORD
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antihypertension, angiotensin converting enzyme, dehydroabietic acid, 4-epi-trans-communic acid, Korean red pine needle
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